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1

Added therapeutic benefit and drug licensing

Eichler, Hans-Georg, Enzmann, Harald, Rasi, Guido

Journal:

Nature Reviews Drug Discovery

Year:

2019

Language:

english

File:

PDF, 520 KB

english, 2019

2

The risks of risk aversion in drug regulation

Eichler, Hans-Georg, Bloechl-Daum, Brigitte, Brasseur, Daniel, Breckenridge, Alasdair, Leufkens, Hubert, Raine, June, Salmonson, Tomas, Schneider, Christian K., Rasi, Guido

Journal:

Nature Reviews Drug Discovery

Year:

2013

Language:

english

File:

PDF, 317 KB

english, 2013

3

Micellar electrokinetic chromatography for the analysis of cefpirome in microdialysis and plasma samples obtained in vivo from human volunteers

Bernhard X. Mayer, Ursula Hollenstein, Martin Brunner, Hans-Georg Eichler, Markus Müller

Journal:

ELECTROPHORESIS

Year:

2000

Language:

english

File:

PDF, 128 KB

english, 2000

4

Diclofenac concentrations in defined tissue layers after topical administration

Müller, Markus, Mascher, Hermann, Kikuta, Christian, Schäfer, Sabine, Brunner, Martin, Dorner, Guido, Eichler, Hans Georg

Journal:

Clinical Pharmacology & Therapeutics

Year:

1997

Language:

english

File:

PDF, 1.87 MB

english, 1997

5

Untersuchungen Über die Wirkung von Giftlattich (Lactuca Virosa) und Seiner Inhaltsstoffe

Oscar Eichler, Hans -Georg Scholtze

Journal:

Journal of Molecular Medicine

Year:

1940

Language:

german

File:

PDF, 523 KB

german, 1940

6

e-SPC: new approaches to delivering drug information

Maxwell, Simon, Eichler, Hans-Georg, Bucsics, Anna, Haefeli, Walter E, Gustafsson, Lars L

Journal:

Future Prescriber

Year:

2012

Language:

english

File:

PDF, 776 KB

english, 2012

7

N-ras oncogene expression changes the growth characteristics of human melanoma in two independent SCID-hu mouse models

Burkhard Jansen, Sue A. Inoue, Hermine Wadl, Hans-Georg Eichler, Klaus Wolff, Andrea Van Elsas, Peter I. Schrier, Hubert Pehamberger

Journal:

International Journal of Cancer

Year:

1996

Language:

english

File:

PDF, 532 KB

english, 1996

8

Influence of MUC18/MCAM/CD146 expression on human melanoma growth and metastasis in SCID mice

Hermine Schlagbauer-Wadl, Burkhard Jansen, Markus Müller, Peter Polterauer, Klaus Wolff, Hans-Georg Eichler, Hubert Pehamberger, Edith Konakand, Judith P. Johnson

Journal:

International Journal of Cancer

Year:

1999

Language:

english

File:

PDF, 78 KB

english, 1999

9

Analysis of microdialysates from cancer patients by capillary electrophoresis

Robert M. Mader, Martin Brunner, Blanka Rizovski, Christa Mensik, Guenther G. Steger, Hans-Georg Eichler, Markus Müller

Journal:

ELECTROPHORESIS

Year:

1998

Language:

english

File:

PDF, 537 KB

english, 1998

10

Effects of cisplatin on urinary thromboxane B2 excretion*

Blöchl-Daum, Brigitte, Pehamberger, Hubert, Kurz, Christine, Kyrle, Paul-Alexander, Wagner, Oswald, Müller, Markus, Monitzer, Brigitte, Eichler, Hans-Georg

Journal:

Clinical Pharmacology & Therapeutics

Year:

1995

Language:

english

File:

PDF, 935 KB

english, 1995

11

Application of microdialysis to clinical pharmacokinetics in humans*

Müller, Markus, Schmid, Rainer, Georgopoulos, Apostolos, Buxbaum, Astrid, Wasicek, Carola, Eichler, Hans-Georg

Journal:

Clinical Pharmacology & Therapeutics

Year:

1995

Language:

english

File:

PDF, 2.09 MB

english, 1995

12

Cerebral and ocular hemodynamic effects of sumatriptan in the nitroglycerin headache model

Schmetterer, Leopold, Wolzt, Michael, Krejcy, Kurt, Graselli, Ursula, Findl, Oliver, Eichler, Hans-Georg, Singer, Ernst A.

Journal:

Clinical Pharmacology & Therapeutics

Year:

1996

Language:

english

File:

PDF, 775 KB

english, 1996

13

Dexamethasone down-regulates the expression of L-selectin on the surface of neutrophils and lymphocytes in humans*

Jilma, Bernd, Voltmann, Jann, Albinni, Said, Stohlawetz, Petra, Schwarzinger, Ilse, Gleiter, Christoph H., Rauch, Alexandra, Eichler, Hans Georg, Wagner, Oswald F.

Journal:

Clinical Pharmacology & Therapeutics

Year:

1997

Language:

english

File:

PDF, 643 KB

english, 1997

14

Effects of antiglaucoma drugs on ocular hemodynamics in healthy volunteers

Schmetterer, Leopold, Strenn, Karin, Findl, Oliver, Breiteneder, Helene, Graselli, Ursula, Agneter, Ernst, Eichler, Hans-Georg, Wolzt, Michael

Journal:

Clinical Pharmacology & Therapeutics

Year:

1997

Language:

english

File:

PDF, 1.21 MB

english, 1997

15

Reversal of endothelin-1—induced ocular hemodynamic effects by low-dose nifedipine in humans

Strenn, Karin, Matulla, Bettina, Wolzt, Michael, Findl, Oliver, Bekes, Maria-Csilla, Lamsfuss, Ulla, Graselli, Ursula, Rainer, Georg, Menapace, Rupert, Eichler, Hans-Georg, Schmetterer, Leopold

Journal:

Clinical Pharmacology & Therapeutics

Year:

1998

Language:

english

File:

PDF, 850 KB

english, 1998

16

Hemodynamic effects of continuous urodilatin infusion: A dose-finding study*

Dorner, Guido T., Selenko, Nicole, Kral, Thomas, Schmetterer, Leopold, Eichler, Hans-Georg, Wolzt, Michael

Journal:

Clinical Pharmacology & Therapeutics

Year:

1998

Language:

english

File:

PDF, 873 KB

english, 1998

17

A double masked placebo controlled study on the effect of nifedipine on optic nerve blood flow and visual field function in patients with open angle glaucoma

Georg Rainer, Barbara Kiss, Susanne Dallinger, Oliver Findl, Michael Georgopoulos, Clemens Vass, Rupert Menapace, Kaija Polak, Hans-Georg Eichler, Michael Wolzt, Leopold Schmetterer

Journal:

British Journal of Clinical Pharmacology

Year:

2001

Language:

english

File:

PDF, 60 KB

english, 2001

18

Characterization of angiotensin-II effects on cerebral and ocular circulation by noninvasive methods

Kurt Krejcy, Michael Wolzt, Claudia Kreuzer, Helene Breiteneder, Wolfgang Schütz, Hans-Georg Eichler, Leopold Schmetterer

Journal:

British Journal of Clinical Pharmacology

Year:

1997

Language:

english

File:

PDF, 363 KB

english, 1997

19

Effects of losartan on cerebral and ocular circulation in healthy subjects

Bettina Matulla, Gabriele Streit, Stefan Pieh, Oliver Findl, Jesusa Entlicher, Ursula Graselli, Hans-Georg Eichler, Michael Wolzt, Leopold Schmetterer

Journal:

British Journal of Clinical Pharmacology

Year:

1997

Language:

english

File:

PDF, 393 KB

english, 1997

20

Exogenous L-arginine does not affect angiotensin II-induced renal vasoconstriction in man

Michael Wolzt, Ara Ugurluoglu, Leopold Schmetterer, Guido Dorner, Gabriele Zanaschka, Christa Mensik, Hans-Georg Eichler

Journal:

British Journal of Clinical Pharmacology

Year:

1998

Language:

english

File:

PDF, 93 KB

english, 1998

21

Direct assessment of peripheral pharmacokinetics in humans: comparison between cantharides blister fluid sampling, in vivo microdialysis and saliva sampling

Martin Brunner, Arno Schmiedberger, Rainer Schmid, Dorothea Jäger, Eveline Piegler, Hans Georg Eichler, Markus Müller

Journal:

British Journal of Clinical Pharmacology

Year:

1998

Language:

english

File:

PDF, 265 KB

english, 1998

22

Pharmacokinetic-pharmacodynamic profile of systemic nitric oxide-synthase inhibition with L-NMMA in humans

Bernhard X. Mayer, Christa Mensik, Sriram Krishnaswami, Hartmut Derendorf, Hans-Georg Eichler, Leopold Schmetterer, Michael Wolzt

Journal:

British Journal of Clinical Pharmacology

Year:

1999

Language:

english

File:

PDF, 125 KB

english, 1999

23

Drug reimbursement: Indicators of inappropriate resource allocation

Bernard Bégaud, Ulf Bergman, Hans-Georg Eichler, Hubert G. M. Leufkens, Peter J. Meier

Journal:

British Journal of Clinical Pharmacology

Year:

2002

Language:

english

File:

PDF, 145 KB

english, 2002

24

Effects of desmopressin on circulating P-selectin

Bernd Jilma, Hans-Georg Eichler, Barbara Vondrovec, Helene Breiteneder, Paul A. Kyrle, Elvira Kitzweger, Stylianos Kapiotis, Wolfgang Speiser

Journal:

British Journal of Haematology

Year:

1996

Language:

english

File:

PDF, 78 KB

english, 1996

25

Heparin lowers plasma levels of activated factor VII

Thomas Pernerstorfer, Bernd Jilma, Hans-Georg Eichler, Susanne Aull, Sylvia Handler, Wolfgang Speiser

Journal:

British Journal of Haematology

Year:

1999

Language:

english

File:

PDF, 149 KB

english, 1999

26

Influence of Increased c-Myc Expression on the Growth Characteristics of Human Melanoma

Schlagbauer-Wadl, Hermine, Griffioen, Marieke, van Elsas, Andrea, Schrier, Peter I., Pustelnik, Tom, Eichler, Hans-Georg, Wolff, Klaus, Pehamberger, Hubert, Jansen, Burkhard

Journal:

The Journal of Investigative Dermatology

Year:

1999

Language:

english

File:

PDF, 411 KB

english, 1999

27

Effects of sodium nitroprusside on hemodialysis-induced platelet activation

JILMA, BERND, HERGOVICH, NICOLE, STOHLAWETZ, PETRA, STUMMVOLL, GEORG, ALBINNI, SAID, SIMAK, SUSANNE, SCHMALDIENST, SABINE, POHANKA, ERICH, EICHLER, HANS-GEORG, KAPIOTIS, STYLIANOS

Journal:

Kidney International

Year:

1999

Language:

english

File:

PDF, 269 KB

english, 1999

28

Renal hemodynamic effects of l-arginine and sodium nitroprusside in heart transplant recipients

Koller-Strametz, Jeanette, Wolzt, Michael, Fuchs, Carola, Putz, Dinah, Wisser, Wilfried, Mensik, Christa, Eichler, Hans-Georg, Laufer, Gunther, Schmetterer, Leopold

Journal:

Kidney International

Year:

1999

Language:

english

File:

PDF, 634 KB

english, 1999

29

Safety issues of plateletpheresis: comparison of the effects of two cell separators on the activation of coagulation, fibrinolysis, and neutrophils and on the formation of neutrophil-platelet aggregates

Petra Stohlawetz, Stylianos Kapiotis, Dagmar Seidl, Nicole Hergovich, Maria Zellner, Hans-Georg Eichler, Gabriele Stiegler, Gerda Leitner, Paul Höcker, Bernd Jilma

Journal:

Transfusion (Wiley)

Year:

1999

Language:

english

File:

PDF, 736 KB

english, 1999

30

Manifestations of new χ(3)- and χ(2)-nonlinear optical interactions and χ(2)-properties of orthorhombic bis(guanidinium) zirconium bis(nitrilotriacetate) hydrate, [C(NH2)3]2Zr[N(CH2COO)3]2·H2O crystal

Alexander A. Kaminskii, Lkhamsuren Bayarjargal, Eiken Haussühl, Nicole Müller, Siegfried Haussühl, Hans J. Eichler, Hanjo Rhee, Ken-ichi Ueda, Akira Shirakawa, Georg A. Reider

Journal:

physica status solidi (a)

Year:

2011

Language:

english

File:

PDF, 1.46 MB

english, 2011

31

Poly(I) · Poly(C), a potential drug carrier for the antitumor agent mitoxantrone: in vitro drug binding study

Hans-Georg Eichler, Robert Mader, Brigitte Blöchl-Daum, Günther Steger, Hugo Rainer

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1987

Language:

english

File:

PDF, 225 KB

english, 1987

32

Clinical experience of targeted therapy

Hans-Georg Eichler

Journal:

Year:

1991

Language:

english

File:

PDF, 994 KB

english, 1991

33

Effect of pituitary adenylate cyclase activating polypeptide 1–27 on ocular, cerebral and skin blood flow in humans

G. T. Dorner, Michael Wolzt, Hans-Georg Eichler, Leopold Schmetterer, H. G. Eichler

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1998

Language:

english

File:

PDF, 62 KB

english, 1998

34

Bcl-2 antisense oligonucleotides chemosensitize human gastric cancer in a SCID mouse xenotransplantation model

Volker Wacheck, Elisabeth Heere-Ress, Julius Halaschek-Wiener, Trevor Lucas, Hildegard Meyer, Hans-Georg Eichler, Burkhard Jansen

Journal:

Journal of Molecular Medicine

Year:

2001

Language:

english

File:

PDF, 212 KB

english, 2001

35

Factors associated with success of market authorisation applications for pharmaceutical drugs submitted to the European Medicines Agency

Jan Regnstrom, Franz Koenig, Bo Aronsson, Tatiana Reimer, Kristian Svendsen, Stelios Tsigkos, Bruno Flamion, Hans-Georg Eichler, Spiros Vamvakas

Journal:

European Journal of Clinical Pharmacology

Year:

2010

Language:

english

File:

PDF, 159 KB

english, 2010

36

Topical fundus pulsation measurements in age-related macular degeneration

L. Schmetterer, Andreas Kruger, Oliver Findl, Helene Breiteneder, Hans-Georg Eichler, Michael Wolzt

Journal:

Graefe's Archive for Clinical and Experimental Ophthalmology

Year:

1998

Language:

english

File:

PDF, 140 KB

english, 1998

37

Outcomes research collaborations between third-party payers, academia, and pharmaceutical manufacturers

Hans-Georg Eichler, Sheldon X. Kong, Jean-Pierre Grégoire

Journal:

The European Journal of Health Economics

Year:

2006

Language:

english

File:

PDF, 732 KB

english, 2006

38

Endomyocardial HLA expression is increased to the same extent in idiopathic and secondary dilated cardiomyopathy

Günter Klappacher, Mohammad Mehrabi, Patrick Franzen, Karina Plesch, Michael Binder, Doris Haab, Susanne Urban, Günter Laufer, H. Dietmar Glogar, Hans-Georg Eichler

Journal:

Immunology Letters

Year:

1994

Language:

english

File:

PDF, 3.19 MB

english, 1994

39

Additional safety risk to exceptionally approved drugs in Europe?

Arna H. Arnardottir, Flora M. Haaijer-Ruskamp, Sabine M. J. Straus, Hans-Georg Eichler, Pieter A. de Graeff, Peter G. M. Mol

Journal:

British Journal of Clinical Pharmacology

Year:

2011

Language:

english

File:

PDF, 945 KB

english, 2011

40

e-SPC – delivering drug information in the 21st century: developing new approaches to deliver drug information to prescribers

Simon Maxwell, Hans-Georg Eichler, Anna Bucsics, Walter E. Haefeli, Lars L. Gustafsson, the e-SPC Consortium

Journal:

British Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 2.87 MB

english, 2012

41

Granulocyte colony-stimulating factor (G-CSF) downregulates its receptor (CD114) on neutrophils and induces gelatinase B release in humans

Bernd Jilma, Nicole Hergovich, Monika Homoncik, Petra Jilma-Stohlawetz, Claudia Kreuzer, Hans-Georg Eichler, Maria Zellner, Jerome Pugin

Journal:

British Journal of Haematology

Year:

2000

Language:

english

File:

PDF, 312 KB

english, 2000

42

Systemic inflammation increases shear stress-induced platelet plug formation measured by the PFA-100

Monika Homoncik, Andrew D. Blann, Ursula Hollenstein, Thomas Pernerstorfer, Hans-Georg Eichler, Bernd Jilma

Journal:

British Journal of Haematology

Year:

2000

Language:

english

File:

PDF, 160 KB

english, 2000

43

Use of Cost-Effectiveness Analysis in Health-Care Resource Allocation Decision-Making: How Are Cost-Effectiveness Thresholds Expected to Emerge?

Hans-Georg Eichler, Sheldon X. Kong, William C. Gerth, Panagiotis Mavros, Bengt Jönsson

Journal:

Value in Health

Year:

2004

Language:

english

File:

PDF, 116 KB

english, 2004

44

Effects of testosterone suppression on serum levels of hepatitis B surface antigen and HBV-DNA in men

Bernd Jilma, Hans-Georg Eichler, Carola Köppl, Beate Weber, Johann P. Pidlich, Peter Ferenci, Christian Müller

Journal:

Liver International

Year:

1998

Language:

english

File:

PDF, 419 KB

english, 1998

45

Absence of age-related changes in venous responsiveness to nitroglycerin in vivo in humans

Eichler, Hans-Georg, Hiremath, Anand, Katzir, Dalia, Blaschke, Terrence F, Hoffman, Brian B

Journal:

Clinical Pharmacology & Therapeutics

Year:

1987

Language:

english

File:

PDF, 329 KB

english, 1987

46

Effect of ritanserin, a 5-hydroxytryptamine2– receptor antagonist, on platelet function and thrombin generation at the site of plug formation in vivo

Wagner, Brunhilde, Schneider, Barbara, Blöchl-Daum, Brigitte, Speiser, Wolfgang, Brenner, Brigitte, Eichler, Hans-Georg, Lechner, Klaus, Kyrle, Paul Alexander

Journal:

Clinical Pharmacology & Therapeutics

Year:

1990

Language:

english

File:

PDF, 442 KB

english, 1990

47

bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

Jansen, Burkhard, Schlagbauer-Wadl, Hermine, Brown, Bob D., Bryan, Robert N., Van Elsas, Andrea, Müller, Markus, Wolff, Klaus, Eichler, Hans-Georg, Pehamberger, Hubert

Journal:

Nature Medicine

Year:

1998

File:

PDF, 458 KB

1998

48

Balancing early market access to new drugs with the need for benefit/risk data: a mounting dilemma

Eichler, Hans-Georg, Pignatti, Francesco, Flamion, Bruno, Leufkens, Hubert, Breckenridge, Alasdair

Journal:

Nature Reviews Drug Discovery

Year:

2008

Language:

english

File:

PDF, 387 KB

english, 2008

49

New drug approval success rate in Europe in 2009

Eichler, Hans-Georg, Aronsson, Bo, Abadie, Eric, Salmonson, Tomas

Journal:

Nature Reviews Drug Discovery

Year:

2010

Language:

english

File:

PDF, 224 KB

english, 2010

50

Systemic and renal effects of an ETA receptor subtype-specific antagonist in healthy subjects

Leopold Schmetterer, Susanne Dallinger, Barbara Bobr, Nicole Selenko, Hans-Georg Eichler, Michael Wolzt

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 304 KB

english, 1998

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